Normally, urine may contain up to 150 mg of protein in 24 hours. In the health two-thirds of urinary protein is constituted by protein of tubular origin, particularly tamm horsfall mucoprotein. Protein derived from plasma namely albumin, immunoglobulin, light chain and beta2 microglobulin constitutes the remaining. Albumin may constitute 10 mg in 24 hrs .In glomerular disease proportion of albumin loss in the urine increases. Proteinuria may result from renal disorders, lesion in urinary tract or extra renal causes like cardiac and fever. A globulin -albumin ratio of <0.1% suggest highly selective proteinuria.
Gross Proteinuria above 3. 5mg in 24 hours occurs in nephrotic syndrome. In about 50% patients with multiple myeloma, light chain of immunoglobulin called bence Jones protein is detected in urine. It may also be seen in other conditions like macroglobulinemia, lymphoma leukemia, amyloidosis and other malignancies.
Some terms
Fixed Proteinuria: >1g/24 hours, mostly of glomerular origin and mainly albumin.
Overflow Proteinuria: light chain of myeloma.
Tubular Proteinuria: <1g/24 hours, mostly protein other than albumin.
Orthostatic Proteinuria: this occurs only when the patient assumes erect posture.
Physiological Proteinuria: this may occur transiently even in normal persons after heavy exertions.
In many types of renal diseases, the severity of Proteinuria is a marker for increased risk of progressive loss of renal function.
Homeopathic treatment.
Homeopathic medicines are highly effective for the treatment of Proteinuria.
Homeopathic medicines like Merc Sol, Lycopodium, Apis, etc. are some among them
